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Biologics immunogenicity and PK/PD
The immunogenic potential of biotherapeutic drug molecules can have an effect at any point, from its administration through to metabolism and elimination. Therefore, it is important to understand the impact of immunogenicity upon the PK and PD properties of a large molecule drug.
The characterization of the effect of anti-drug antibodies on the PK is critical. The development of a physiologically relevant PK model in the context of the immunogenicity profile offers significant value to preclinical development.
We offer technology platforms that enable in vitro, ex vivo, and in vivo evaluations to help you understand the immunogenicity of your biologics.
Automated Liquid Handling
We've been providing liquid handling solutions for over 40 years to help labs accelerate their science.
Microfluidic Nucleic Acid Analysis
Now you can simplify traditional gel separations, while improving the reproducibility of your data in a fraction of the time.
In Vivo Imaging Instruments
Whether you’re trying to understand biology pathways, monitor disease progression, or evaluate drug candidates earlier in drug development, our wide portfolio of preclinical imaging systems are designed to meet your research needs.
High Content Screening Instruments
High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level.
Cellular Imaging Software
Revvity offers sophisticated cellular imaging and analysis software to help you acquire, visualize, analyze and share your image data more effectively and efficiently, so you can spend more time discovering.
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
In vitro assay
Leverage reliable in vitro assays to help better understand the interactions of the innate and adaptive immune response for your discovery and development of immunotherapies
We offer a range of assays for characterizing cytokine response, screening biologics, measuring signalling events, determining mechanism of action, and understanding the antibody-dependent cellular cytotoxicity (ADCC) of the biologic.
Luminescence Assays
Luciferase assays allow for the study of transcriptional gene expression, virus life cycles, and cell viability.
Radiometric Detectors
Radiometric detection has long been and remains today as the gold standard used by researchers in many scientific applications such as analyzing drug pathways, protecting lab environments, assessing environmental contamination, and monitoring food safety.
Radionuclides
Radionuclides provide a highly specific and sensitive labeling option for proteins, cells, and tissues.
Immune Cell Screening
Preclinical screening services using primary human immune cells to address biologically relevant questions for target identification and lead optimization
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.
Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
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