Efficient single-base genomic perturbations for next-gen screens and cell model generation
Choose base editing services that can improve cell viability and survival over traditional CRISPR methods by avoiding double strand DNA breaks. Single base changes can be used to evaluate protein function, study drug-gene interactions, model diseases, or safely multiplex gene knockouts.
With our Pin-point™ base editing services, you can benefit from:
- Precise edits with clear and predictable mutations
- Avoid double strand DNA breaks
- High viability and cell health after editing
- Ideal for iPSCs and primary immune cells
- Save time and resources by leveraging our team’s expertise
In addition to our base editing services, we also offer Pin-point base editing reagents and licensing to the underlying patents and patent applications to provide broad access to base editing across the research and therapeutic market.
Pin-point™ base editing reagents are available for research use only and are not for diagnostic use or direct administration into humans or animals. The Pin-point™ base editing platform technology is available for clinical or diagnostic study and commercialization under a commercial license from Revvity.
Pooled tiled screening services
With the Pin-point platform, screens can be designed to tile guide RNAs across entire gene sequences, enabling the generation of precise C-to-T mutations. This facilitates the selection of guides for therapeutic applications, identification of critical amino acids in structure-function analysis, examination of ligand binding relationships in drug candidate screening, and validation of target identity among other applications.
Our team of scientists from our Preclinical Services team will work with you to generate high-quality, reproducible data that you can trust.
With the Pin-point platform, screens can be designed to tile guide RNAs across entire gene sequences, enabling the generation of precise C-to-T mutations. This facilitates the selection of guides for therapeutic applications, identification of critical amino acids in structure-function analysis, examination of ligand binding relationships in drug candidate screening, and validation of target identity among other applications.
Our team of scientists from our Preclinical Services team will work with you to generate high-quality, reproducible data that you can trust.
Cell line engineering services
The ability to make complex edits in a single editing experiment allows for the knockout of multiple genes in a single clonal cell line. This helps reduce experimental timelines and improve turnaround times, while also limiting cell viability challenges. Avoiding double strand DNA breaks reduces the risk of genomic aberrations that might otherwise compromise cell line performance. Utilize multiplexed gene knockout for improved disease modeling, target validation, and biological pathway analysis.
Partner with our in-house Preclinical Services team, who will guide you through the process and perform the experimental work for you, delivering the next-generation cell models you need for your next ground-breaking project.
The ability to make complex edits in a single editing experiment allows for the knockout of multiple genes in a single clonal cell line. This helps reduce experimental timelines and improve turnaround times, while also limiting cell viability challenges. Avoiding double strand DNA breaks reduces the risk of genomic aberrations that might otherwise compromise cell line performance. Utilize multiplexed gene knockout for improved disease modeling, target validation, and biological pathway analysis.
Partner with our in-house Preclinical Services team, who will guide you through the process and perform the experimental work for you, delivering the next-generation cell models you need for your next ground-breaking project.
Contact us today to discuss how we can help you accelerate your research with our base editing services.
