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Physiological Model Solutions

Enhance the relevance of your research

Drug discovery endeavors require a deep understanding of biological systems and their response to potential therapeutics. That’s where physiological disease models play a pivotal role. They offer a more accurate representation of cellular biology that goes beyond traditional approaches, enabling researchers to understand disease mechanisms and find new treatments that translate into clinical response.

If you are working on your next 3D cell project, and trying to select the right culture method, genetically modify your cells, automate your workflow, or analyze your samples and data, at Revvity we have the technologies and solutions to partner with you with the purpose of reaching your goals. Together, we can redefine what’s possible by developing innovative treatments and precise therapeutic solutions to improve human health and lives around the world.

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For research use only. Not for use in diagnostic procedures.

Physiological Model Solutions

Explore our solutions

Culture Treatment Model Analysis Data Analysis
Culture

When it comes to developing advanced physiological models — it’s critical to select the cell model with the right genomic context and biological function to recapitulate a healthy or diseased phenotype.

Achieving this level of accuracy requires tightly controlled culture conditions and reliable cell counting for cell seeding. Choosing a 2D or 3D culture method depends on the biological question, complexity of the desired model, and readout technology. Cells can be grown as monolayers, single spheroids in ultra-low attachment (ULA) plates, or cultured in hydrogels, offering a variety of options to enhance your research capabilities. Count on us to expertly scale up these methods, utilizing liquid handling techniques.

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Treatment

In modern drug discovery, multiple screening methods play a vital role in identifying potential drug targets and eventual drug candidates. Traditionally, small molecule libraries were screened for compounds acting on a known molecule or for a desired biological effect. However, a drug candidate is only as good as its target.

To ensure the utmost precision, today’s drug discovery leverages gene editing or gene silencing methods such as CRISPR or siRNAs to identify suitable drug targets. Understanding the causal gene behind a phenotype or genes that contribute to a phenotype can significantly boost the confidence in a new drug candidate. Get ready to experience advancements in your research as we deliver convenience and efficiency.

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Model Analysis

Selecting the right method for measuring the biological response of 3D models depends on the specific research question and the characteristics of the model system in use.

Whether you’re repeatedly monitoring microtissue size or measuring sensitive detection of secreted proteins, each readout type poses unique challenges that can be overcome with the right tools. Our microplate readers, high-content analysis systems, and innovative reagents are complemented by specially designed microplates. Together, they shine a light on your samples, offering powerful insights to propel your research forward.

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Data Analysis

Extracting insights from complex 3D datasets is no easy task. It requires the meticulous analysis of readouts and vast amounts of information (in context). But no worries—we’ve got you covered.

With our scientific software and informatics solutions, you gain the ultimate tools to optimize 3D cell model imaging. Seamlessly aggregate, search, mine, and visualize critical data, converting it into actionable insights that drive your research forward. We are here to help you meet the challenges of data analysis head on—so you can embark on a journey of ground-breaking discoveries.

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Signals VitroVivo
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Explore our resources
Publication review

Unlocking the potential of cancer immunotherapy- Overcoming the challenges of 3D immune cell killing assays

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White paper

Establishing an automated high-throughput assay that supports the growth of prostate cancer organoids

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White paper

Genetically engineered PDX models as patient avatars in preclinical evaluation of acute leukemias

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Application note

Multi-parametric high-throughput analysis of hepatotoxicity using a 3D primary liver cell culture model

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White paper

Therapeutic targeting of the tumor microenvironment

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Publication review

Revolutionizing neurodegenerative disease research with brain-on-chip technology

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eBook

Upscaling organoid research for sharper biological insights

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Technical note

Automated high-content assay using GrowDex-embedded spheroids dispensed on JANUS G3 automated liquid handling workstation

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Publication review

Organ-on-chips- increased complexity for higher physiological relevance in pharmaceutical safety testing

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