Overview
IVISense™ Acute Vascular (formerly Genhance) are small molecule fluorescent probes that can be used as a control or in vascular permeability imaging/blood pooling. IVISense Acute Vascular enables imaging of circulation, blood vessels, and the vasculature. It is typically imaged using intravital microscopy (IVM). IVISense Acute Vascular 680 is the acid form of IVISense 680 NHS Fluorescent Self-Quenching Dye (formerly VivoTag 680), and IVISense Acute Vascular 750 is the acid form of IVISense 750 NHS Fluorescent Self-Quenching Dye (formerly VivoTag 750). Both probes come in two sizes (1 mg and 5 mg).
Products and catalog numbers
| Product | Catalog number | Ex/Em wavelength (nm) | Molecular weight (g/mol) | Validated Experiments | Applications |
|---|---|---|---|---|---|
| IVISense Acute Vascular 680 (1 mg) |
NEV10117 | 670/688 | ~ 1646 | In vivo | Control Vascular |
| IVISense Acute Vascular 680 (5 mg) |
NEV10130 | 670/688 | ~ 1646 | In vivo | Control Vascular |
| IVISense Acute Vascular 750 (1 mg) |
NEV10118 | 750/775 | 1086 | In vivo | Control Vascular |
| IVISense Acute Vascular 750 (5 mg) |
NEV10177 | 750/775 | 1086 | In vivo | Control Vascular |
Using IVISense Acute Vascular probe for in vivo studies
| Product | Route of Injection | Mouse Dose (25 g) | Rat Dose (250 g) | Blood t 1/2 | Tissue t 1/2 | Optimal imaging time | Optimal Re-injection Time (complete clearance) | Route of Metabolism/ background tissue | FMT & IVIS settings |
|---|---|---|---|---|---|---|---|---|---|
| IVISense Acute Vascular 680 | IV | 50 ug | 150-500 ug | 0.5 h | not determined | 0.5 h | not determined | Bladder | FMT 680/700 IVIS 675/720 |
| IVISense Acute Vascular 750 | IV | 50 ug | 150-500 ug | 0.5 h | not determined | 0.5 h | not determined | Bladder | FMT 750/770 IVIS 745/800 |
For research use only. Not for use in diagnostic procedures.